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目的：探讨腹腔内注射重组人肿瘤坏死因子（ｒｈＴＮＦ）对卵巢癌裸鼠腹水瘤形态学的影响。方法：建立卵巢癌裸鼠腹水瘤模型。实验组每只裸鼠腹腔内注入ｒｈＴＮＦ１万Ｕ加注射用水１ｍｌ的稀释液，对照组腹腔内注入注射用水１ｍｌ。用光镜和电镜观察形态学改变。结果：肿瘤细胞有不同程度的改变。结论：ｒｈＴＮＦ有不同程度杀伤肿瘤细胞的作用，促使癌细胞趋向死亡。
Objective: To investigate the effect of intraperitoneal injection of recombinant human tumor necrosis factor (rhTNF) on the morphology of ovarian cancer in nude mice. Methods: To establish ovarian cancer ascites tumor model in nude mice. Experimental group, each nude mice were injected intraperitoneally with rhTNF1 U plus 1 ml of water for injection, and 1 ml of water for injection into the control group. Morphological changes were observed with light and electron microscopy. Results: Tumor cells have varying degrees of change. Conclusion: rhTNF can kill tumor cells to some extent and cause cancer cells to die.