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目的探讨阴道上皮内瘤变(VAIN)的临床特征、治疗及预后。方法对大连市妇产医院2009～2011年住院的32例VAIN患者的临床资料进行回顾性分析,并对其定期随访。结果 32例VAIN患者中12例进行了HPV检测,10例(83.3%)阳性。22例(68.8%)病变位于阴道上段,10例(31.2%)位于阴道下段。4例VAIN持续存在,且均为多病灶分布,但未发现浸润癌发生。结论 VAIN发病与HPV感染密切相关,病变多位于阴道上段或下段,手术治疗有效,多病灶分布为VAIN持续存在高危因素。
Objective To investigate the clinical features, treatment and prognosis of vaginal intraepithelial neoplasia (VAIN). Methods The clinical data of 32 VAIN patients hospitalized in Dalian Maternity Hospital from 2009 to 2011 were retrospectively analyzed and followed up regularly. Results Of the 32 patients with VAIN, HPV was detected in 12 patients and 10 (83.3%) were positive. Twenty-two patients (68.8%) were located in the upper vagina and 10 (31.2%) in the lower vaginal. 4 cases of VAIN persisted, and were multifocal distribution, but did not find invasive carcinoma. Conclusion The incidence of VAIN is closely related to HPV infection. Most of the lesions are located in the upper or lower vagina. Surgical treatment is effective. The distribution of multiple lesions is the risk factor of persistent VAIN.