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背景为了评估重组抗血友病因子中的人类微小病毒 B19(B19)传播的危险性,作者比较了798例2到7岁的血友病男童中B19的血清发病率。作者采集他们的关节功能数据, 用于评估B19血清携带状况与关节活动受限(ROM)之间的关系。研究设计及方法 US血友病治疗中心的工作人员采集治疗用制品的类型和10处关节的ROM资料,并提供了血液标本
Background In order to assess the risk of the spread of human parvovirus B19 (B19) in recombinant anti-haemophilic factor, the authors compared the serum incidence of B19 in 798 boys aged 2 to 7 years with hemophilia. The authors collected their joint function data to assess the relationship between B19 serum carrier status and restricted joint mobility (ROM). Study Design and Methods Staff at the US Hemophilia Treatment Center collected the types of therapeutic articles and ROM data from 10 joints and provided blood samples