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采用动态心电图对30例经皮冠状动脉成形术(PTCA)的病人进行术后监测,并检测血中超氧化物歧化酶(SOD)和丙二醛(MDA)浓度的自由基指标动态变化。结果显示:PTCA术服用四逆汤的术后心肌缺血程度和再灌注心律失常发生率比单纯PTCA术更为显著地改善(p<0.05),其机制在于四逆汤能升高SOD活性和降低MDA含量,减轻PTCA术后心肌缺血再灌注损伤。
Postoperative monitoring of 30 patients undergoing percutaneous transluminal coronary angioplasty (PTCA) was performed using dynamic electrocardiogram, and the dynamic changes of free radical indices of superoxide dismutase (SOD) and malondialdehyde (MDA) in blood were detected. The results showed that the incidence of postoperative myocardial ischemia and reperfusion arrhythmia after PTCA was more significantly improved than that of PTCA alone (p<0.05). The mechanism was that Sini Decoction could increase the activity of SOD and Reduce MDA content and reduce myocardial ischemia and reperfusion injury after PTCA.