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原阿片碱来自延胡索的干燥块茎。作者通过体内、外实验模型对原阿片碱的血小板聚集作用作了研究。结果表明原阿片碱对由胶原、花生四烯酸钠和二磷酸腺苷(ADP)诱发的小鼠肺血栓有抑制作用,对胶原、ADP诱发的大鼠体外血小板聚集也有抑制作用。其效力相当或优于阿司匹林、潘生丁。体外实验,通过环腺苷酸(cAMP)和花生四烯酸二者代谢系统的研究,阐述了原阿片碱的血小板聚集作用机制。原阿片碱能增加cAMP在血小板中的含量,也能增强兔血小板中腺苷酸环化酶的活性,但对cAMP-磷酸二脂酶无效。在血小板中的TXA_2的生
The original opiate was derived from dry tubers of Corydalis. The authors studied platelet aggregation of primary opiates by in vitro and in vivo models. The results showed that protopine inhibited pulmonary thrombosis in mice induced by collagen, sodium arachidonic acid and adenosine diphosphate (ADP), and inhibited platelet aggregation induced by collagen and ADP in vitro. Its effectiveness is equal to or better than aspirin and dipyridamole. In vitro experiments, through the study of the metabolic system of cyclic adenosine monophosphate (cAMP) and arachidonic acid, elucidated the platelet aggregation mechanism of protopine. The original opioid can increase the cAMP content in platelets, but also can enhance the activity of adenylyl cyclase in rabbit platelets, but it is not effective for cAMP- phosphodilipase. TXA_2 in platelets