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目的:探讨宫颈上皮内瘤变LEEP治疗前后HPV16/18的变化及其意义。方法:对通过宫颈活组织病理和阴道镜检查诊断为CIN并接受LEEP术治疗的200例患者检测在LEEP手术前及手术后6、18个月的HPV16/18水平。结果:LEEP术前CINI、CINⅡ、CINⅢ宫颈组织HPV16/18阳性率分别为42.0%、63.6%、81.8%,术后6个月三者HPV16/18阳性率分别为1.9%、15.2%、27.35,术后12个月检测HPV16/l8阳性率分别为0.0%、1.5%,18.2%。三组CIN患者术前与术后6、12个月的HPV16/18阳性率相比差异有统计学意义(P<0.05)。结论:LEEP手术可以显著减少HPV16/18的阳性率,有效预防宫颈上皮内瘤变。
Objective: To investigate the changes and significance of HPV16 / 18 before and after treatment of cervical intraepithelial neoplasia (LEEP). Methods: Two hundred and seventy patients diagnosed as CIN by cervical biopsy and colposcopy were enrolled in this study. LEV and HPV16 / 18 levels were measured before LEEP and at 6 and 18 months after surgery. Results: The positive rates of HPV16 / 18 in cervical tissues of CINI, CINⅡ and CINⅢ before LEEP were 42.0%, 63.6% and 81.8% respectively. The positive rates of HPV16 / 18 were 1.9%, 15.2% and 27.35 respectively at 6 months after LEEP, The positive rate of HPV16 / l8 detected at 12 months after surgery was 0.0%, 1.5% and 18.2% respectively. The positive rates of HPV16 / 18 in three groups of CIN patients before surgery and 6 and 12 months after surgery were significantly different (P <0.05). Conclusion: LEEP can significantly reduce the positive rate of HPV16 / 18 and effectively prevent cervical intraepithelial neoplasia.