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本文将31例胃肠癌患者分为治疗组和对照组（未加服硒），观察术前投药前后血清硒浓度与T淋巴细胞亚群、NK细胞的活性的变化。结果显示：胃肠癌患者入院时血硒水平为0．825±0．11μmol／L，低于正常对照组，口服硒剂后血硒浓度升高，与对照组相比差异有显著性（P＜0．05），服硒后血中CD3、CD4、CD8细胞以及CD4／CD8细胞比值仍维持原有水平，但对照组有所下降（P＜0．05），值得注意的是服硒后患者血中NK细胞活性明显升高，与对照组相比差异显著。结果表明：术前适量补充有机硒能在短期内可作为一个有效的辅助治疗。
In this paper, 31 patients with gastrointestinal cancer were divided into treatment group and control group (selenium was not added), and the changes of serum selenium concentration, T lymphocyte subsets, and NK cell activity before and after preoperative administration were observed. The results showed that the blood selenium level was 0.825±0.11 μmol/L on admission in patients with gastrointestinal cancer, which was lower than that in the normal control group. Selenium concentration increased after oral selenium treatment, and there was a significant difference compared with the control group (P). <0.05) The ratios of CD3, CD4, CD8 cells and CD4/CD8 cells in blood after selenium treatment still maintained their original levels, but the control group decreased (P < 0.05). It is worth noting that after serving Selenium The activity of NK cells in the blood of patients was significantly higher than that of the control group. The results showed that the appropriate amount of organic selenium before surgery can be used as an effective adjuvant therapy in the short term.