报告我院经手术病理证实的Ⅲ,Ⅳ期乳腺癌874例。治疗分A、B两组,A组先行局部治疗,然后辅以全身化疗;B组先用全身化疗再行手术和放疗,继之巩固化疗和内分泌等综合治疗。结果表明:B组的2年生存率,5年生存率,复发率及转移率明显优于A组(P<0.01)。认为加强全身治疗并合理配合局部治疗的综合疗法,是提高晚期乳腺癌疗效的有效方法。 Reported 874 cases of stage III and IV breast cancer confirmed by surgery in our hospital. The treatment was divided into two groups: A and B. Group A received local treatment first, followed by systemic chemotherapy. Group B first used systemic chemotherapy to perform surgery and radiotherapy, followed by consolidation of chemotherapy and endocrine therapy. The results showed that the 2-year survival rate, 5-year survival rate, recurrence rate and metastasis rate in group B were significantly better than those in group A (P<0.01). It is believed that comprehensive therapy that enhances systemic therapy and rationally cooperates with local therapy is an effective method for improving the efficacy of advanced breast cancer.