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目的探讨氨氯地平阿托伐他汀钙片治疗高血压合并高脂血症的疗效。方法选取2012年2月—2014年2月北京市仁和医院收治的高血压合并高脂血症患者80例,随机分为对照组与观察组,各40例。对照组患者予以氨氯地平片治疗,观察组患者予以氨氯地平阿托伐他汀钙片治疗。观察两组患者治疗前后血压(收缩压、舒张压)变化、血脂〔三酰甘油(TG)、低密度脂蛋白(LDL)、总胆固醇(TC)、高密度脂蛋白(HDL)〕变化及不良反应发生情况。结果治疗前两组患者收缩压和舒张压比较,差异无统计学意义(P>0.05),治疗后观察组收缩压和舒张压低于对照组,差异有统计学意义(P<0.05);治疗前两组患者TG、LDL、TC、HDL比较,差异无统计学意义(P>0.05),治疗后观察组患者TG、LDL、TC低于对照组,HDL-C高于对照组,差异有统计学意义(P<0.05);观察组患者不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论氨氯地平阿托伐他汀钙片治疗高血压合并高脂血症的疗效显著,能有效降低患者血压与血脂水平,提高患者生活质量,减少不良反应。
Objective To investigate the therapeutic effect of amlodipine atorvastatin calcium on patients with hypertension and hyperlipidemia. Methods Eighty patients with hypertensive hyperlipidemia admitted to Renhe Hospital of Beijing from February 2012 to February 2014 were randomly divided into control group and observation group, 40 cases each. Patients in the control group were given amlodipine tablets, and patients in the observation group were given amlodipine atorvastatin calcium tablets. The changes of blood pressure (systolic and diastolic blood pressure) and changes of blood lipids (triglyceride (TG), low density lipoprotein (LDL), total cholesterol (TC) and high density lipoprotein (HDL) Reaction occurred. Results There was no significant difference in systolic and diastolic blood pressure between the two groups before treatment (P> 0.05). After treatment, the systolic and diastolic blood pressures in the observation group were lower than those in the control group (P <0.05) There was no significant difference in TG, LDL, TC and HDL between the two groups (P> 0.05). After treatment, TG, LDL and TC in the observation group were lower than those in the control group, HDL-C was higher than that in the control group (P <0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, with significant difference (P <0.05). Conclusion Amlodipine atorvastatin calcium treatment of hypertension with hyperlipidemia significant effect, can effectively reduce blood pressure and blood lipid levels, improve patient quality of life, reduce adverse reactions.