硬结症是呼吸道一种进行极慢的感染性肉芽肿,1870年 Hebra 首次报告此病,Frisch 氏杆菌可能为引起此病的病原菌。解放前,硬结症在我国被认为是一种非常罕见的疾病,文献上报导不多,如:1927年林外男氏报告此病三例,1931年 Garben 报告一例,1945年林筱周氏报告一例,同年李漪氏等报告二例,此外 Weed 等1938年报告一例女性 Scleroderma is an extremely slow respiratory granulomatosis. Hebra first reported the disease in 1870, and Frischiella may be the causative agent of the disease. Before the liberation, Sclerosis in our country is considered as a very rare disease, there are few reports in the literature, such as: 1927 Men’s Lynch reported three cases of the disease, 1931 Garben report one case, 1945 Lin Xiao Zhou reported a case, In the same year, Li Yi’s other reports were two cases. In addition, Weed et al. Reported a case of women in 1938