以卡介苗(BCG)与蒸馏水混合后,给家兔和犬从输精管向付睾尾部注射。注射后30天,犬的睾丸内出现明显的生精障碍,付睾中精子数近于零,间质细胞功能无损害。血浆睾丸酮水平在注射前后无明显变动。BCG对家兔的影响不如犬严重。上述结果提示输精管内注射BCG是一简便而安全的免疫避孕方法。 After BCG and distilled water are mixed, the rabbits and dogs are injected from the vas deferens to the caudal tail. Thirty days after injection, there were obvious spermatogenic disorders in the testes of dogs. The number of spermatozoa in the testis was almost zero, and the function of interstitial cells was not damaged. Plasma testosterone levels did not change significantly before and after injection. The effect of BCG on rabbits is worse than that of dogs. These results suggest that intravital injection of BCG is a simple and safe method of immunocontraceptive.