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目的:探讨叉状头/翅膀状螺旋转录因子3(Foxp3)和膜突蛋白(Moesin)在非小细胞肺癌(NSCLC)组织的表达及临床意义。方法:收集广东医科大学附属医院2016年4月至2020年12月病理学确诊的102例NSCLC患者癌组织标本和对应癌旁组织标本，采用免疫组织化学法检测上述组织中Foxp3以及Moesin表达水平，采用n χ2检验统计学分析两者与NSCLC临床病理参数的关系。n 结果:NSCLC组织Foxp3蛋白阳性表达率为65.69%(67/102)、对应癌旁组织Foxp3蛋白阳性表达率[22.55%(23/102)]，两者差异有统计学意义(n χ2＝38.494，n P<0.01)；Foxp3表达水平与NSCLC淋巴结转移、TNM分期(TNM stage)明显相关(n χ2＝5.890、4.603，n P<0.05)。NSCLC组织Moesin蛋白阳性表达率为83.33%(85/102)、对应癌旁组织Moesin蛋白阳性表达率[15.69%(16/102)]，两者差异有统计学意义(n χ2＝93.362，n P<0.01)；Moesin表达水平与NSCLC组织学分化程度、淋巴结转移、TNM分期明显相关(n χ2＝8.483、4.910、4.175，n P<0.05)。n 结论:Foxp3和Moesin表达上调与NSCLC患者病情密切相关，有助于评估NSCLC发生、侵袭转移和预后。“,”Objective:To investigate the expression and clinical significance of forkhead box P3 (Foxp3) and membrane-organizing extension spike protein (Moesin) in non-small cell lung cancer (NSCLC).Methods:Foxp3 and Moesin expression in 102 cases of human NSCLC tissues and non-cancerous adjacent lung tissues pathologically confirmed from April 2016 to December 2020 on Affiliated Hospital of Guangdong Medical University was examined by using envision immunohistochemistry. The statistical analysis of Chi-square test was carried out in combination with the relationships between the expression of Foxp3 and Moesin and the clinicopathological features of NSCLC.Results:Foxp3 expression in NSCLC tissues and the non-cancerous adjacent lung tissues was 65.69% (67/102) and 22.55% (23/102) respectively, and differences were statistically significant (n χ2=38.494, n P<0.01). The expression of Foxp3 was associated with NSCLC to lymph node metastasis and tumor node metastasis stage (TNM stage) (respectively,n χ2=5.890, 4.603, n P<0.05). Moesin expression in NSCLC tissues and the non-cancerous adjacent lung tissues was 83.33% (85/102) and 15.69% (16/102) respectively, and differences were statistically significant (n χ2=93.362, n P<0.01). The expression of Moesin was associated with NSCLC to histology grade, TNM stage and lymph node metastasis (respectively,n χ2=8.483, 4.910, 4.175, n P<0.05).n Conclusion:Foxp3 and Moesin up-regulation is closely related to disease status of patients with NSCLC, which may be indicators of the occurrence, invasion, metastasis and prognosis of NSCLC.