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目的探讨尿脱氧吡啶啉(uDPD)对肺癌骨转移诊断的意义。方法 182例肺癌患者分骨转移组和未发现骨转移组,进行 uDPD/尿肌酐(uCr)比值、尿钙(uCa)/uCr、血清钙(sCa)、血清碱性磷酸酶(sAKP)比较,并对其在肺癌骨转移诊断的灵敏度、特异度作比较。同时,对其中80例肺癌未发现骨转移患者进行6个月的追踪观察。结果肺癌骨转移组 uDPD/Cr 为[(12.35±2.65)nmoL/mmo1],高于肺癌未发现骨转移组[(7.76±2.11)nmol/mmol,t=2.46,P<0.01];其诊断肺癌骨转移的灵敏度、特异度分别为81.4%和70%;80例肺癌无骨转移患者初测 uDPD/uCr 比值正常组6个月后骨转移率为17.4%,初测 uDPD/uCr 比值升高组6个月后骨转移率为55.9%;两组差异有统计学意义(X~2=12.95,P<0.01)。结论 uDPD 对肺癌骨转移诊断和与监测有较大临床意义。
Objective To investigate the significance of urinary deoxy-pyridine (uDPD) in the diagnosis of bone metastasis of lung cancer. Methods The uDP / uCr ratio, uCa / uCr, sCa and sAKP were compared among 182 patients with lung cancer and those without bone metastasis. And compared its sensitivity and specificity in diagnosis of bone metastasis of lung cancer. At the same time, 80 cases of lung cancer patients without bone metastasis were observed for 6 months. Results The uDPD / Cr in lung cancer patients with bone metastasis was (12.35 ± 2.65) nmoL / mmo1 higher than that in patients without lung cancer (7.76 ± 2.11 nmol / mmol, t = 2.46, P <0.01) The sensitivity and specificity of bone metastasis were 81.4% and 70% respectively. The bone metastasis rate was 17.4% in the 80 cases of non-bone metastasis of lung cancer and the uDPD / uCr ratio of the normal group was 17.6% The bone metastasis rate was 55.9% after 6 months. The difference between the two groups was statistically significant (X ~ 2 = 12.95, P <0.01). Conclusion uDPD has great clinical significance in diagnosis and monitoring of bone metastasis of lung cancer.