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牛胰蛋白酶抑制剂具用广泛的蛋白酶抑制活性,在机体中参与凝血、纤溶、细胞迁移、细胞分化、调亡和炎症反应等,在临床上应用于细胞调亡、凝血、骨质疏松和肿瘤等的治疗。本文综述了牛胰蛋白酶抑制剂的分子结构和功能及生物学特性,牛胰蛋白酶抑制剂的临床应用及对脏器保护的应用等进行探讨。
Bovine trypsin inhibitor with a wide range of protease inhibitory activity in the body involved in coagulation, fibrinolysis, cell migration, cell differentiation, apoptosis and inflammatory response, etc., in clinical application to apoptosis, coagulation, osteoporosis and Tumor and other treatment. This review summarizes the molecular structure and function of bovine trypsin inhibitor and its biological characteristics, the clinical application of bovine trypsin inhibitor and the application of organ protection.