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[目的]分析吸烟与否、吸烟时程及平均吸烟指数对激素治疗特发性肺纤维化治疗的影响,指导临床治疗效果评价。[方法]对2003年10月～2007年10月就诊于华北煤炭医学院附属医院呼吸内科住院的特发性肺纤维化(IPF)患者130例进行回顾性分析。[结果]IPF患者中,吸烟组患者较不吸烟组患者对激素治疗敏感性较差(P﹥0.05);吸烟时程长患者较吸烟时程短患者对激素治疗敏感性较差(P﹥0.05);平均吸烟指数高的患者较平均吸烟指数低的患者对激素治疗敏感性较差(P﹥0.05)。[结论]不吸烟组、吸烟时程短、平均吸烟指数低较吸烟组、吸烟时程长、平均吸烟指数高对激素治疗敏感性高。
[Objective] To analyze the influence of smoking or not, smoking duration and average smoking index on the treatment of idiopathic pulmonary fibrosis by hormone therapy, and to guide the evaluation of clinical treatment effect. [Methods] A retrospective analysis of 130 patients with idiopathic pulmonary fibrosis (IPF) who were hospitalized in Department of Respiratory Medicine of North China Coal Medical College from October 2003 to October 2007 was performed. [Results] Among patients with IPF, the patients in the smoker group were less sensitive to hormone therapy than those in the non-smoker group (P> 0.05), while those with smoking duration were less sensitive to steroid treatment than those with short smoking duration ). Patients with higher average smoking index than those with lower average smoking index had poorer sensitivity to hormone therapy (P> 0.05). [Conclusion] The non-smoking group had shorter smoking duration and lower average smoking index than the smoking group, longer smoking duration and higher average smoking index were more sensitive to hormone therapy.