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高血压、糖尿病、吸烟等心血管病危险因素均可导致动脉僵硬,其主要的临床表现是单纯的收缩期高血压和脉压差增大。大动脉僵硬与动脉粥样斑块的发展密切相关。目前评估大动脉僵硬的方法主要有脉压差和主动脉脉搏速度等。肾上腺素、去甲肾上腺素和血管内皮细胞释放的一氧化氮(NO)和内皮素1对大动脉僵硬具有调节作用。本文对大动脉僵硬及NO的调节作用进行综述。
Hypertension, diabetes, smoking and other risk factors for cardiovascular disease can lead to arterial stiffness, the main clinical manifestations of simple systolic hypertension and pulse pressure increased. Aortic stiffness is closely related to the development of atherosclerotic plaques. The current assessment of aortic stiffness methods are mainly pulse pressure and aortic pulse rate. Epinephrine, norepinephrine, and nitric oxide (NO) released from vascular endothelial cells and endothelin 1 have a modulatory effect on aortic stiffness. This article reviews the regulation of aortic stiffness and NO.