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目的通过检测直肠癌组织CD133的表达并分析其与临床病理参数的相关性,探讨其在临床应用中的价值。方法免疫组化法检测116例直肠癌与癌旁切缘正常组织中CD133蛋白的表达,分析两组间的差异以及癌组织中CD133与临床病理参数性别、年龄、肿瘤直径、分化程度、浸润深度、淋巴结转移与否、p TNM分期的相关性。结果直肠癌组织与癌旁组织中CD133的阳性表达率分别为66.4%、8.6%,两者差异有统计学意义(P<0.05),癌组织中CD133高表达阳性率为33.6%,低表达阳性率为32.8%;癌组织CD133高表达与组织分化程度、淋巴结转移与否呈正相关,相关系数分别为0.453、0.408,与肿瘤直径、肿瘤浸润深度、临床分期无显著相关。结论直肠癌组织中CD133阳性表达率在一定程度上体现直肠癌生物学行为,可作为直肠癌恶性程度判断的新的分子指标应用于病情的评估。
Objective To detect the expression of CD133 in rectal cancer and analyze its correlation with clinicopathological parameters and to explore its value in clinical application. Methods Immunohistochemistry was used to detect the expression of CD133 protein in 116 cases of rectal cancer and adjacent normal tissues. The differences between the two groups were analyzed, and the relationship between CD133 and clinical pathological parameters such as sex, age, tumor diameter, differentiation, depth of invasion , Lymph node metastasis or not, p TNM stage correlation. Results The positive rates of CD133 in rectal cancer tissues and adjacent tissues were 66.4% and 8.6%, respectively (P <0.05). The positive rate of CD133 in cancer tissues was 33.6% The rate was 32.8%. The high expression of CD133 in cancer tissue was positively correlated with the degree of differentiation and lymph node metastasis. The correlation coefficients were 0.453 and 0.408, respectively. There was no significant correlation between CD133 expression and tumor diameter, tumor invasion depth and clinical stage. Conclusion The positive expression rate of CD133 in rectal cancer can reflect the biological behavior of rectal cancer to a certain extent. It can be used as a new molecular marker to judge the malignant degree of rectal cancer.