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为进一步证实稀土元素的抗肿瘤作用，并探讨其抑癌作用机理，以体外培养的人胃癌细胞ＰＡＭＣ８２为研究对象，观察镧、铈元素对癌细胞生长的抑制作用，降低恶性程度的逆转作用及对细胞中癌基因、抑癌基因表达水平的影响。氯化镧、氯化铈和混合氯化稀土在０．５～１．５ｍｍｏｌ／Ｌ浓度下可显著抑制癌细胞生长。并使ＰＡＭＣ８２细胞形态、微管结构发生类似正常细胞的转变。在软琼脂中的生长能力下降。抑癌基因ｐ５３、ｐ１６和ｐ２１表达水平上升，ｎｍ２３基因表达水平下降。
In order to further confirm the anti-tumor effect of rare earth elements and explore its anti-cancer mechanism, the human gastric cancer cell PAMC82 cultured in vitro was used as the research object to observe the inhibitory effect of lanthanum and cerium elements on the growth of cancer cells and to reduce the reversal of malignancy. Effects on the expression levels of oncogenes and tumor suppressor genes in cells. Barium chloride, strontium chloride and mixed rare earth chloride can significantly inhibit the growth of cancer cells at concentrations of 0.5-1.5 mmol/L. And make PAMC82 cell morphology, microtubule structure similar to normal cell transformation. The ability to grow in soft agar decreases. The expression of tumor suppressor genes p53, p16 and p21 increased, and the expression of nm23 gene decreased.