大然自身抗体（ｎａｔｕｒａｌ ａｕｔｏａｎｔｉｂｏｄｙ，ＮＡＡ）是指在没有任何抗原主动免疫的情况下，正常机体内天然产生并存在的针对一种或多种自身抗原的免疫球蛋白。历史上人们对ＮＡＡ的认识经历了一个复杂而矛盾的过程，从一开始把所有的自身抗体一概看作是“可怕的 Natural autoantibodies (NAA) refer to immunoglobulins against one or more autoantigens that are naturally produced and present in the normal body in the absence of any active immunization of the antigen. Historically, people’s understanding of NAA has undergone a complex and contradictory process, from the outset of all the autoantibodies as "terrible