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对33例结核性脑膜炎患儿进行短程间歇化疗。以雷米封、利福定、吡嗪酰胺及链霉素在日用一个月后改为每周二次,链霉素续用1～2个月, 雷米封、利福定、吡嗪酰胺续用8个月。对照组16例结核性脑膜炎患儿上述四药日用坚持一年以上。研究表明,短程间歇化疗与全程日用对照组的疗效相似(P>0.05)。其后遗症发生率治疗组与对照组间亦无显著差异(P>0.05),且与入院时脑脊液白细胞数、蛋白质、糖和氯化物水平无紧密关联(P>0.05),可是,有昏迷抽风者,后遗症的发生率明显增加(P<0.05)。
Thirty-three children with tuberculous meningitis were treated with short-range intermittent chemotherapy. Remy packer, rifadin, pyrazinamide and streptomycin in the daily one month later changed to twice a week, streptomycin continued for 1 to 2 months, reesei, rifadin, pyrazinamide Continued with 8 months. Control group of 16 patients with tuberculous meningitis, the four drugs daily for more than a year. Studies have shown that short-term intermittent chemotherapy and full daily control group similar efficacy (P> 0.05). There was no significant difference in the incidence of sequelae between the treatment group and the control group (P> 0.05), and there was no significant correlation between the sequelae incidence and the levels of white blood cell, protein, glucose and chloride in CSF (P> 0.05) , The incidence of sequelae increased significantly (P <0.05).