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目的：对比促排卵药对多囊卵巢综合征不孕症的治疗效果及对子宫内膜病理的影响。方法：B超监测45例病人接受克罗米酚（CC）、HMG或CC／HMG后卵泡的发育情况，观察用药前后子宫内膜的病理变化。结果：CC／HMG诱导排卵可获得40％的妊娠率且黄素化卵泡不破裂综合征及过度刺激综合征发生率低；用药前后子宫内膜增殖症的发生率有显著性差异（P＜0．05）。结论：CC失败者应用CC／HMG可取得满意疗效；促排卵药物可改善子宫内膜的病理状态，有助于子宫内膜癌的预防；黄体功能不全及间质发育不良可能是多囊卵巢综合征高排卵低妊娠率的原因之一。
Objective: To compare the therapeutic effect of ovulation induction drugs on sterility of women with polycystic ovary syndrome and its effect on endometrial pathology. Methods: Forty-five patients underwent B-mode ultrasound to monitor the development of follicles after clomiphene citrate (CC), HMG or CC / HMG. The pathological changes of the endometrium were observed before and after treatment. Results: 40% pregnancy rate was found in ovulation induced by CC / HMG and the incidence of luteinizing follicle without rupture syndrome and hyperstimulation syndrome was low. The incidence of endometrial hyperplasia was significantly different between before and after treatment (P <0.05 ). CONCLUSIONS: CC failure patients can achieve satisfactory curative effect by using CC / HMG. Ovulation drugs can improve the pathological state of endometrium and help to prevent endometrial cancer. Luteal phase dysfunction and interstitial dysplasia may be polycystic ovary syndrome One of the reasons for low pregnancy rate of high ovulation sign.