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结核分枝杆菌感染后,巨噬细胞凋亡被认为是抵抗其进一步入侵的重要机制之一,巨噬细胞发生凋亡后可以杀死胞内的结核分枝杆菌,进一步地加工、递呈抗原,激活邻近尚未感染的巨噬细胞,增强机体的免疫应答能力。结核分枝杆菌也会通过一系列机制来抑制巨噬细胞的凋亡,以逃避巨噬细胞的杀伤。结核分枝杆菌对宿主巨噬细胞凋亡的调控呈现出复杂性和多面性,进一步研究其具体调控机制有助于人们更好地预防和控制结核病。
Mycobacterium tuberculosis infection, macrophage apoptosis is considered one of the important mechanisms to resist its further invasion, macrophage apoptosis can kill intracellular Mycobacterium tuberculosis, further processing, presentation of antigen , Activate neighboring macrophages that have not yet been infected, and enhance the body’s immune response. Mycobacterium tuberculosis also inhibits macrophage apoptosis through a series of mechanisms to evade macrophage killing. Mycobacterium tuberculosis apoptosis in host macrophage show complexity and versatility, and further study of its specific regulatory mechanisms will help people better prevent and control of tuberculosis.