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目的:探讨针对肾功能不全并感染耐药性金黄色葡萄球菌(即MRSA)的患者采用万古霉素杀菌治疗时,进行给药方案优化的临床意义。方法:选取30例感染MRSA的患者作为本次的研究对象,将15例肾功能不全者分为研究组,将另外15例肾功能正常者分为参考组,对两组患者在采用万古霉素进行MRSA杀菌治疗后的肾功能变化进行对比分析。结果:应用万古霉素对于参考组治疗前后尿素氮比较差异无统计学意义(P>0.05),研究组治疗前后尿素氮比较差异具有统计学意义(P<0.05),并对用药不合理的患者进行用药调整。结论:应用万古霉素时根据血药的检测结果以及患者肾功能临床表现进行给药方案的合理调整,并进行个性化用药方式,能够有效提高治疗效果。
OBJECTIVE: To investigate the clinical significance of optimization of dosing regimen for vancomycin-resistant patients with renal insufficiency and drug-resistant Staphylococcus aureus (MRSA). Methods: Thirty patients with MRSA infection were enrolled in this study. Fifteen patients with renal insufficiency were divided into study group and another 15 patients with normal renal function were divided into reference group. The patients in two groups were treated with vancomycin After the MRSA bactericidal treatment of renal function changes were compared. Results: There was no significant difference between the two groups (P> 0.05) before and after the treatment with vancomycin. There was significant difference between the two groups before and after treatment (P <0.05), and the patients with unreasonable medication Medication adjustment. Conclusion: When vancomycin is used, reasonable adjustment of dosage regimen according to the test result of blood drug and clinical manifestations of renal function of patients, and personalized treatment can effectively improve the therapeutic effect.