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目的探讨乌司他丁对重度烧伤患者早期重要脏器功能的作用并观察其对白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平的影响。方法将40例重度烧伤患者随机分为实验组和对照组,每组20例,对照组按常规抗休克、创面处理和营养治疗,实验组在常规抗休克、创面处理和营养治疗的基础上加用乌司他丁,测定两组血标本ALT、AST、CK、BUN、Cr、IL-8及TNF-α浓度。结果患者入院即刻查血ALT、AST、CK、BUN、Cr、IL-8及TNF-α浓度均明显增高,两组差异无统计学意义(P﹥0.05)。用药第3天、第7天实验组血ALT、AST、CK、BUN、Cr、IL-8及TNF-α浓度较对照组明显下降,两组差异有统计学意义(P<0.05)。结论乌司他丁能减轻由细胞炎性因子介导的炎性反应,有效保护重度烧伤患者早期各脏器功能。
Objective To investigate the effect of ulinastatin on the function of early vital organs in severe burn patients and to observe its effects on the levels of interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α). Methods Forty patients with severe burn were randomly divided into experimental group and control group, with 20 cases in each group. The control group was treated with conventional anti-shock, wound treatment and nutrition treatment. The experimental group was given conventional anti-shock, wound treatment and nutrition treatment The concentrations of ALT, AST, CK, BUN, Cr, IL-8 and TNF-α in blood samples were measured with ulinastatin. Results The blood levels of ALT, AST, CK, BUN, Cr, IL-8 and TNF-α were significantly increased at admission. There was no significant difference between the two groups (P> 0.05). The levels of ALT, AST, CK, BUN, Cr, IL-8 and TNF-α in the experimental group on the 3rd and 7th day after treatment decreased significantly compared with those in the control group (P <0.05). Conclusion Ulinastatin can reduce the inflammatory reaction mediated by cellular inflammatory factors and effectively protect the function of early organs in severe burn patients.