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目的 探讨血清PON 1酶活性、PON 1Q192R基因多态性与湖南汉族慢性肾衰病人的关系。方法 对 79例湖南汉族慢性肾衰病人及 90例对照组的血清PON 1酶蛋白水平、PON 1Q192R基因多态性进行检测。结果 慢性肾衰病人组血清PON 1酶活性 ( 3 72 6± 15 0 6)U显著低于对照组 ( 5 3 7 8± 172 2 )U ,两者比较 ,差异有显著性 (P <0 0 1) ;慢性肾衰病人组PON 1AB +BB基因型频率明显高于对照组 ,基因型AB +BB/AA的优势比为 6 3 9( 95 %可信限为 2 5 0～ 16 3 5 ,P <0 0 1)。结论 PON 1基因表达与湖南汉族人慢性肾衰疾病发生有关 ,AB +BB基因型可能系慢性肾衰疾病中的危险因子
Objective To investigate the relationship between serum PON 1 activity, PON 1Q192R polymorphism and chronic renal failure patients in Hunan Han nationality. Methods Serum PON 1 protein levels and PON 1Q192R polymorphism were detected in 79 patients with chronic renal failure and 90 controls in Hunan Han nationality. Results The serum PON 1 enzyme activity (3 72 6 ± 150 6) U in patients with chronic renal failure was significantly lower than that in the control group (53 7 8 ± 172 2) U, the difference was significant (P 0 0 1). The frequency of PON 1AB + BB genotype in patients with chronic renal failure was significantly higher than that in control group. The odds ratio of genotype AB + BB / AA was 6 3 9 (95% confidence interval was 250 ~ 163 5, P <0 0 1). Conclusion The expression of PON 1 is related to the occurrence of chronic renal failure in Hunan Han population. The genotype of AB + BB may be the risk factor of chronic renal failure