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目的分析女性不孕症患者血清及宫颈黏液中自身抗体检测对病情的评估价值。方法选取2012年7月-2014年7月间至该院接受检查的女性不孕患者138例作为观察组对象。另取同期在该院因宫颈炎症接受检查的已育女性106例作为对照组。比较两组研究对象的血清及宫颈黏液自身抗体水平、外周血调解性T细胞(Treg)水平,进一步分析观察组患者中自身抗体与Treg水平的相关性。结果 1观察组患者的血清及宫颈黏液中抗精子抗体(AsAb)、抗卵巢抗体(AoAb)、抗人绒毛膜促性腺激素(AhCGAb)、抗子宫内膜抗体(EMAb)、甲状腺自身抗体(ATA)、抗-β-2糖蛋白1抗体(α-β-2GP1)水平高于对照组女性(P<0.05);2观察组患者的外周血Treg水平低于对照组(P<0.05);3不孕症女性血清及宫颈黏液中的AsAb、AoAb、AhCGAb、EMAb、ATA、α-β-2GP1等自身抗体水平与外周血Treg水平呈负相关(P<0.05)。结论女性不孕症患者血清及宫颈黏液中自身抗体水平大幅上升,与患者的疾病发生发展以及病情严重程度均关系密切,是临床诊断及指导治疗的理想指标。
Objective To analyze the diagnostic value of autoantibodies in serum and cervical mucus of women with infertility. Methods A total of 138 female infertility patients who were admitted to the hospital from July 2012 to July 2014 were selected as the observation group. Another take the same period in the hospital due to cervical inflammation checked fertile female 106 cases as a control group. The levels of serum and cervical mucus autoantibodies and the levels of Tregs in peripheral blood were compared between the two groups. The correlation between autoantibodies and Tregs in the observation group was further analyzed. Results 1 In the observation group, serum anti-sperm antibody (AsAb), anti-ovarian antibody (AoAb), anti-human chorionic gonadotropin (AhCGAb), anti-endometrial antibody (EMAb), thyroid autoantibodies (P <0.05). The level of Treg in the peripheral blood of the observation group was lower than that of the control group (P <0.05); 3 The level of α-β-2GP1 in the observation group was significantly higher than that of the control group The levels of autoantibodies such as AsAb, AoAb, AhCGAb, EMAb, ATA and α-β-2GP1 in serum and cervical mucus of infertile women were negatively correlated with the level of Treg in peripheral blood (P <0.05). Conclusion The levels of autoantibodies in serum and cervical mucus of women with infertility have risen sharply and are closely related to the development of the disease and the severity of the disease. It is an ideal indicator for clinical diagnosis and treatment.