【摘 要】
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In order to quantify the poroelastic mechanical signals conduction and evaluate the biomechanical effectiveness of functional units (osteocyte processes,canalic
【机 构】
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College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China;College o
论文部分内容阅读
In order to quantify the poroelastic mechanical signals conduction and evaluate the biomechanical effectiveness of functional units (osteocyte processes,canaliculi and lacuna) in lacunar-canalicular system (LCS),a multiscale poroelastic finite element model was established by using the Comsol Multiphysics software.The poroelastic mechanical signals (pore pressure,fluid velocity,von-Mises stress,strain) were analyzed inside the osteon-osteocyte system.The effects of osteocyte (OCY)'s shape (ellipse and circle),long axis directions (horizontal and vertical) and mechanical properties (Elastic modulus and permeability) on its poroelastic responses were examined.It is found that the OCY processes is the best mechanosensor compared with the OCY body,lacunae and canaliculi.The mechanotransduction ability of the elliptic shaped OCY is stronger than that of circular shaped.The pore pressure and flow velocity around OCYs increase as the elastic modulus and permeability of OCY increase.The established model can be used for studying the mechanism of bone mechanotransduction at the multiscale level.
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