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胃肠道除消化、吸收、分泌功能及免疫调节外,还具有重要的屏障功能。在创伤、休克、严重感染、脓毒症等应激情况下胃肠道黏膜易受到攻击和损害而发生屏障功能障碍,出现腹痛、腹胀、腹泻或消化道出血等症状。胃肠道屏障功能受损后,应激状态下的胃肠道就成为机体内最大的细菌库和毒素库,可诱发和加重全身炎性反应和多器官功能障碍。因此,探讨胃肠道屏障功能障碍的防治有重要的临床意义。近年来,应用中医药疗法保护肠屏障取得了良好的效果,对其保护作用机制的研究越来越受到重视。中医中药对胃肠屏障功能障碍的治疗,主要从整体出发,辨证论治,已有许多临床与动物实验研究证实中药大黄等具有明显保护胃肠屏障的功能,现将近年来大黄治疗胃肠道屏障功能障碍的研究进展综述如下。
Gastrointestinal in addition to digestion, absorption, secretion and immune regulation, but also has an important barrier function. In the trauma, shock, severe infection, sepsis and other stress conditions, gastrointestinal mucosa vulnerable to attack and damage barrier dysfunction, abdominal pain, abdominal distension, diarrhea or gastrointestinal bleeding and other symptoms. Gastrointestinal barrier dysfunction, the stress state of the gastrointestinal tract has become the body’s largest bacterial pool and toxin pool, can induce and aggravate the systemic inflammatory response and multiple organ dysfunction. Therefore, to explore the prevention and treatment of gastrointestinal barrier dysfunction have important clinical significance. In recent years, the application of traditional Chinese medicine therapy to protect the gut barrier has achieved good results, more and more attention has been paid to its protective mechanism. Chinese medicine on the gastrointestinal barrier dysfunction treatment, mainly from the overall, syndrome differentiation, there are many clinical and animal studies have confirmed that traditional Chinese medicine such as rhubarb has a significant protective function of the gastrointestinal barrier, rhubarb now in recent years, the treatment of gastrointestinal barrier dysfunction The research progress is summarized as follows.