论文部分内容阅读
目的:探讨肝硬化患者凝血功能变化与其肝功能分级的关系。方法:测定68例肝硬化患者(肝硬化组)的凝血酶原时间(PT)、激活部分凝血激酶时间(APTT)、纤维蛋白原(FIB)及凝血酶时间(TT),并与40例非肝硬化正常体检者(对照组)的PT、APTT、FIB、TT进行对比分析,同时比较肝硬化不同Child-Pugh分级的PT、APTT、FIB、TT差异。结果:肝硬化组较对照组PT、APTT、TT均有明显延长,FIB有显著下降,组间比较有显著差异(P<0.01);根据肝硬化Child-Pugh分级A→B→C顺序,PT、APTT、TT逐渐延长,FIB值逐渐下降,各组间比较均有显著差异(P<0.05或P<0.01)。结论:肝硬化患者肝功能受损程度与凝血功能的改变密切相关,且随着肝功能损害程度的加重,凝血障碍愈明显。
Objective: To investigate the relationship between coagulation changes and liver function classification in patients with cirrhosis. Methods: Prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and thrombin time (TT) were measured in 68 patients with cirrhosis (cirrhosis) The levels of PT, APTT, FIB and TT in patients with normal liver cirrhosis (control group) were compared and analyzed. The differences of PT, APTT, FIB and TT in patients with cirrhosis and Child-Pugh grading were also compared. Results: The levels of PT, APTT and TT in cirrhosis group were significantly longer than those in control group (P <0.01), and the FIB was significantly decreased (P <0.01). According to Child-Pugh classification of A → B → C, , APTT, TT gradually extended, FIB value gradually decreased, and there was significant difference among the groups (P <0.05 or P <0.01). Conclusion: The degree of hepatic impairment in patients with cirrhosis is closely related to the change of coagulation function. And with the aggravation of liver dysfunction, the coagulation disorder is more obvious.