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目的 :了解多发性骨髓瘤 (MM)骨髓活检切片的变化 ,评价骨髓切片在MM中的意义。方法 :运用塑料包埋切片技术观察了 43例MM患者的骨髓切片 ,并与涂片进行比较。结果 :MM骨髓切片中浆细胞以结节状及大片状浸润为主 ,这种浸润方式对MM诊断的敏感性达 88.4% ,明显高于涂片中浆细胞 >15 %作为指标的敏感性 (6 5 .1% ) ;浸润方式能较客观地反映患者的肿瘤量分级与临床分期 ;切片中骨髓增生程度也显著高于涂片。结论 :与涂片比较 ,MM的骨髓切片有一定优越性 ,对MM的诊断、化疗方案的选择及预后估计具有重要意义。
Objective: To understand the changes of multiple myeloma (MM) bone marrow biopsy and to evaluate the significance of bone marrow biopsy in MM. Methods: The bone marrow sections of 43 patients with MM were observed by plastic embedding technique and compared with smear. Results: The number of plasma cells in MM bone marrow was mainly nodular and extensive infiltration. The sensitivity of this infiltration method to MM diagnosis was 88.4%, which was significantly higher than that of smears with> 15% plasma cells (65.1%). The infiltration method could objectively reflect the tumor grade and clinical stage of patients. The degree of myeloproliferation in the slices was also significantly higher than that of the smears. Conclusion: Compared with smear, MM bone marrow slices have certain superiority, which is of great significance for the diagnosis of MM, the choice of chemotherapy regimen and prognosis.