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目的:探讨系统性红斑狼疮(SLE)患者血清免疫球蛋白E(IgE)水平及临床意义。方法:选择2018年1月至2019年6月日照市中心医院诊治的SLE患者62例为观察组，健康志愿者30例为健康对照组，过敏性疾病患者30例为过敏组。检测并比较观察组、健康对照组及过敏性疾病组IgE水平的差异；比较活动期、缓解期SLE患者IgE水平的差异；检测并比较活动期、缓解期SLE患者与健康对照组补体C3、C4及抗双链脱氧核糖核酸(ds-DNA)的差异。分析IgE水平与SLE疾病活动的相关性。结果:观察组、健康对照组及过敏组IgE水平分别为(126.5±51.6)kU/L、(31.2±9.9)kU/L、(316.5±152.6)kU/L，差异有统计学意义(n F＝91.263，n P<0.05)；其中，过敏组IgE水平最高，显著高于观察组及健康对照组；观察组显著高于健康对照组，均差异有统计学意义(n t＝14.375、18.593、7.210，均n P<0.05)；活动期SLE患者IgE水平为(201.65±75.5)kU/L，显著高于缓解期SLE患者的(35.6±13.5)kU/L，差异有统计学意义(n t＝12.241，n P<0.05)；活动期SLE患者C3、C4分别为(0.55±0.20)g/L、(0.13±0.04)g/L，均显著低于缓解期SLE患者的(0.86±0.35)g/L、(0.28±0.10)g/L及健康对照组的(0.92±0.39)g/L、(0.30±0.12)g/L，抗ds-DNA抗体(36.97±12.52)%，显著高于缓解期SLE患者及健康对照组，均差异有统计学意义(n F＝11.303、29.993、197.902，均n P0.05)。IgE水平与狼疮疾病活动性指数(SLE-DAI)评分及抗ds-DNA呈显著正相关(n r＝0.842、0.823，均n P<0.05)；IgE水平与C3及C4水平呈显著负相关(n r＝－0.798、－0.807，均n P<0.05)。n 结论:系统性红斑狼疮患者IgE水平升高，但低于过敏性疾病患者，且IgE水平与疾病活动性有关。“,”Objective:To explore the clinical value of serum IgE detection in patients with systemic lupus erythematosus (SLE).Methods:From January 2018 to June 2019, 62 SLE patients in Rizhao Central Hospital were selected as the observation group, 30 healthy volunteers were selected in the control group, and 30 patients with allergic diseases were selected in the allergic diseases group.The difference of IgE level among the observation group, the healthy control group and the allergic disease group was detected and compared.The difference of IgE level between active and remission SLE patients was compared.The complement C3, C4 and anti ds-DNA in active and remission SLE patients and healthy controls were detected and compared.The correlation between the level of IgE and the disease activity of SLE was analyzed.Results:The levels of IgE were (126.5±51.6)kU/L, (31.2±9.9)kU/L, (316.5±152.6)kU/L in the observation group, control group and the allergic disease group, respectively, the difference was statistically significant (n F=91.263, n P<0.05). The level of IgE in the allergic disease group was the highest, which was significantly higher than that in observation group and healthy control group; and the IgE level of the observation group was significantly higher than that of the control group, the differences were statistically significant (n t=14.375, 18.593, 7.210, all n P<0.05). The level of IgE in active SLE patients was (201.65±75.5)kU/L, which was significantly higher than that in remission SLE patients [(35.6±13.5)kU/L], the difference was statistically significant (n t=12.241, n P<0.05). The C3 and C4 levels in active SLE patients were (0.55±0.20)g/L and (0.13±0.04)g/L, respectively, which were significantly lower than those in the remission SLE patients [(0.86±0.35)g/L, (0.28±0.10)g/L] and the control group [(0.92±0.39)g/L, (0.30±0.12)g/L], and the percentage of anti ds-DNA antibody [(36.97±12.52)%] was significantly higher than that of SLE patients and control group, the differences were statistically significant (n F=11.303, 29.993, 197.902, all n P0.05). The IgE level was positively correlated with SLEDAI score and anti ds-DNA (n r=0.842, 0.823, all n P<0.05). IgE level was negatively correlated with C3 and C4 levels (n r=-0.798, -0.807, all n P<0.05).n Conclusion:The level of IgE in SLE patients is higher than that in allergic patients.The level of IgE is related to disease activity.