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硼氢化钠是一种温和、高选择性的亲核还原剂。一般它只能还原醛、酮和酰氯,而对其它功能团不起作用。因而其应用范围有一定的限制。据文献报道,某些金属卤化物能有效地提高硼氢化钠的还原性能。复合还原剂硼氢化钠/三氯化铁已应用于将β-二烷基氨基共轭烯酮还原为相应的饱和γ-氨基醇。本文研究了硼氢化钠/三氯化铁对亚砜的还原反应。
Sodium borohydride is a mild, highly selective nucleophilic reducing agent. In general, it can only reduce aldehydes, ketones and acid chlorides, but not to other functional groups. Thus its scope of application has some restrictions. According to the literature, some metal halides can effectively improve the reduction performance of sodium borohydride. The complex reductant sodium borohydride / ferric chloride has been used to reduce the [beta] -dialkylaminoconjugated enone to the corresponding saturated [gamma] -aminoalcohol. This article studies the reduction of sulfoxide by sodium borohydride / ferric chloride.