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目的:通过经皮重复给予大鼠不同浓度含轻粉玉红膏,考察体内汞的吸收及蓄积情况,为临床安全用药提供科学依据。方法:将100只SD大鼠随机分成5组:对照组、玉红膏组、2倍浓度玉红膏组、4倍浓度玉红膏组和1.6%轻粉组。于破损皮肤重复给药(剂量为0.04 g·cm-2)2周、4周和停药4周时,分别测定大鼠血、尿中汞含量和心、肝、脑、肾组织中汞的蓄积量。结果:连续给药4周时,玉红膏组大鼠血中汞含量与对照组比较无明显差异,其他各实验组随着给药时间的延长和给药剂量的增高,吸收入血的汞含量和尿中汞的排泄量均明显增高。给药4周时,实验组各组织汞含量均升高,其中肾最高,脑最低。停药4周时,各实验组大鼠血、尿中汞含量均恢复正常,各组织汞含量明显下降。结论:玉红膏经破损皮肤给予大鼠4周,吸收入血的汞量甚微,体内汞的蓄积主要在肾脏,汞主要从尿液排泄。提示临床长期使用玉红膏应监测患者体内汞含量和肾功能指标。
OBJECTIVE: To study the absorption and accumulation of mercury in vivo by different doses of light pink jade cream, and to provide a scientific basis for clinical safe medication. Methods: 100 SD rats were randomly divided into 5 groups: control group, Yu Hong cream group, 2 times concentration Yuhong cream group, 4 times concentration Yuhong cream group and 1.6% light powder group. The blood and urine mercury contents and the contents of mercury in heart, liver, brain and kidney were measured respectively after repeated dosing of damaged skin (0.04 g · cm-2) for 2 weeks, 4 weeks and 4 weeks after drug withdrawal Volume accumulation. Results: After 4 weeks of continuous administration, there was no significant difference in the blood mercury levels between the two groups. In the other experimental groups, Content and urinary mercury excretion were significantly higher. At 4 weeks after administration, the contents of mercury in experimental tissues increased, with the highest in kidney and the lowest in brain. At 4 weeks after withdrawal, the mercury levels in blood and urine of rats in each experimental group returned to normal, and the mercury content in each tissue decreased significantly. CONCLUSION: Jade red ointment was given to the rats for 4 weeks after the damaged skin. Mercury absorption into the blood was negligible. The accumulation of mercury in the body was mainly in the kidney, and mercury was mainly excreted from the urine. Prompted clinical long-term use of Yu Hong cream should be monitored in patients with mercury content and renal function indicators.