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目的探讨阿托伐他汀对原发性高血压患者心肌肥厚的逆转效果。方法将64例确诊为原发性高血压患者随机分为观察组和对照组,观察组31例,对照组33例。对照组给予拉西地平4mg/d,观察组在对照组基础上添加阿托伐拉汀10mg/d,疗程均为8个月。分别于治疗前后记录两组患者心肌肥厚和心脏舒张功能情况,对比两组临床疗效。结果治疗前两组患者血压水平、舒张末期室间隔厚度、舒张末期左室后壁厚度、左室舒张末期内径,左心射血分数及左心重量指数比较,差异未见统计学意义(P>0.05);治疗后两组血压水平、超声心动图指标较治疗前下降(P<0.05),且观察组SBP及其平均压低于对照组(P<0.05)。结论阿托伐汀治疗原发性高血压能降低血压,增强患者心肌收缩能力,可有效改善LVMI,逆转心肌肥厚。
Objective To investigate the effect of atorvastatin on myocardial hypertrophy in patients with essential hypertension. Methods 64 patients diagnosed as essential hypertension were randomly divided into observation group and control group, 31 cases in observation group and 33 cases in control group. The control group received lacidipine 4mg / d, and the observation group received atorvastatin 10mg / d on the basis of the control group. The course of treatment was 8 months. The changes of cardiac hypertrophy and diastolic function were recorded in two groups before and after treatment, and the clinical efficacy was compared between the two groups. Results There was no significant difference in blood pressure level, end-diastolic septal thickness, left ventricular posterior wall thickness, left ventricular end-diastolic diameter, left ventricular ejection fraction and left ventricular mass index in the two groups before treatment (P> 0.05). After treatment, the levels of blood pressure and echocardiography in both groups were lower than those before treatment (P <0.05), and the mean SBP and the mean pressure in the observation group were lower than those in the control group (P <0.05). Conclusion Atorvastatin treatment of essential hypertension can lower blood pressure, enhance myocardial contractility, can effectively improve LVMI, reverse myocardial hypertrophy.