目的:观察益肾化湿颗粒配合洛丁新治疗慢性肾小球肾炎的临床效果。方法:将68例慢性肾小球肾炎患者随机分为治疗组36例与对照组32例。2组患者均给予洛丁新(盐酸贝那普利片)口服,治疗组在此基础上加用益肾化湿颗粒口服,比较2组患者治疗前后24h尿蛋白定量变化及临床疗效。结果:总有效率治疗组为91.7%,对照组为62.5%,2组间比较,差异有显著性意义(P<0.05)。治疗组在减少24h尿蛋白定量方面优于对照组,2组比较,差异有显著性意义(P<0.05)。2组治疗前后血常规、血糖、血脂、肝肾功能无明显变化,治疗组未发现明显的不良反应。结论:益肾化湿颗粒配合洛丁新治疗慢性肾小球肾炎比单用洛丁新效果好,具有临床应用价值。 Objective: To observe the clinical effect of Yishen Huashi granule in combination with lodindin in the treatment of chronic glomerulonephritis. Methods: Sixty-eight patients with chronic glomerulonephritis were randomly divided into treatment group (36 cases) and control group (32 cases). The patients in both groups were given oral administration of Luodingxin (benazepril hydrochloride tablets) orally. On the basis of this, the treatment group was treated with Yishen Huashui granules orally, and the changes of 24-hour urinary protein and clinical efficacy were compared between the two groups before and after treatment. Results: The total effective rate was 91.7% in the treatment group and 62.5% in the control group. There was significant difference between the two groups (P <0.05). The treatment group was better than the control group in reducing 24 h urinary protein quantitation. There was significant difference between the two groups (P <0.05). Before and after treatment, blood routine, blood glucose, blood lipid, liver and kidney function had no significant changes in the two groups, and no obvious adverse reactions were found in the treatment group. Conclusion: YISHUNHUA granules combined with LODIN treatment of chronic glomerular nephritis than the new single effect of Ludding, with clinical value.