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作者比较了何杰金氏病(HD)病人及其它恶性肿瘤病人、原发性睾丸功能衰竭及正常人的垂体-睾丸功能。 19例未曾治疗的HD病人,年龄19～41岁,Ⅰ_A、Ⅱ_A、Ⅲ_B、Ⅳ_B期各3例,Ⅲ_A期6例,Ⅳ_A期1例,其中13例无症状,6例有症状。其它恶性肿瘤患者11例,年龄20～34岁;其中5例非何杰金氏淋巴瘤,3例转移性腺癌,多发性骨髓瘤、慢性粒细胞白血病和下颌骨骨肉瘤各1例。全部患者均来用过影响垂体-睾丸功能的药。对照组包括13例18～54岁的原发性睾丸功能衰竭者[血清促黄体生成素(LH)、滤泡刺激素(FSH)水平均升高]和19例男性、年龄23～36岁的正常人。全部人员进行精液分析,测定血清LH、FSH、催乳素、总睾丸酮(T)和游离T、17羟孕酮(17OHP)水平,以及绒毛膜促性激素(HCG)刺激试验。结果:HD患者的基础血清T浓度比正常人低27％(P<0.01),但比原发性睾丸功能衰竭者高26％
The authors compared pituitary-testicular function in patients with Hodgkin’s disease (HD) and other malignant tumors, with primary testicular failure and in normal subjects. Nineteen untreated patients with HD were aged 19 to 41 years. There were 3 cases in each of groups Ⅰ_A, Ⅱ_A, Ⅲ_B and Ⅳ_B, 6 cases in stage Ⅲ_A and 1 case in stage Ⅳ_A, of which 13 cases were asymptomatic and 6 cases were symptomatic. Eleven patients with other malignant tumors, aged 20 to 34 years old, including 5 non-Hodgkin’s lymphoma, 3 metastatic adenocarcinoma, multiple myeloma, chronic myeloid leukemia and 1 case of mandibular osteosarcoma respectively. All patients come to have used the medicine that affects pituitary-testicular function. The control group consisted of 13 primary testicular failure patients aged 18-54 [elevated serum LH and FSH levels] and 19 male, aged 23-36 years Normal people. All the staffs were semen analyzed to determine the levels of serum LH, FSH, prolactin, total testosterone (T) and free T, 17hydroxyprogesterone (17OHP) and chorionic gonadotropin (HCG) stimulation test. Results: The basal serum T concentration of HD patients was 27% lower than that of normal people (P <0.01), but higher than that of primary testicular failure patients by 26%