20年前,Arias-Stella首次报道高原世居者颈动脉体增大伴敏感性降低。继而Smith等发现颈动脉体增大与右室肥大程度高度相关,提示肺动脉高压;他们同时发现颈动脉体增大并与左室肥大相关;进一步分析表明这种左室肥大仅见于体循环高压患者,先天性主动脉瓣狭窄者则不然。据Honig等报道,颈动脉体化学感受器还可影响肾功能,包括钠的重吸收和肾素-血管紧张素的释放,甚至影响“盐食欲”。这样,颈动脉体在心血管调节中 Twenty years ago, Arias-Stella first reported a decrease in susceptibility to carotid body enlargement in highland natives. Followed by Smith and other found that increased carotid body and right ventricular hypertrophy were highly correlated, suggesting pulmonary hypertension; they also found that carotid body increased and associated with left ventricular hypertrophy; further analysis showed that this LVH only found in patients with systemic hypertension, Congenital aortic stenosis is not. According to Honig et al, carotid body chemoreceptors can also affect renal function, including sodium reabsorption and release of renin-angiotensin, even affecting “salt appetite.” In this way, the carotid body is in cardiovascular regulation