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目的:研究牛膝的化学成分。方法:采用D101型大孔吸附树脂、硅胶、ODS和制备型高效液相色谱等分离手段,运用NMR等波谱技术鉴定化合物的结构。结果:从牛膝中分离并鉴定了2个阿魏酰胺苷和7个皂苷类化合物:N-trans-feruloyl-3-methoxytyramine-4′-O-β-D-glucopyranoside(1),N-trans-feruloyl-3-methoxytyramine-4-O-β-D-glucopyranoside(2),PJS-1(3),chikusetsusaponinIVa(4),oleanolicacid3-O-[β-D-glucuronopyranoside-6-O-methylester]-28-O-β-D-glucopyranoside(5),oleanolicacid3-O-[β-D-glucuronopyranoside-6-O-ethylester]-28-O-β-D-glucopyranoside(6),oleanolicacid3-O-[β-D-glucurono-pyranoside-6-O-butylester]-28-O-β-D-glucopyranoside(7),ginsenosideR0(8)和hederagenin-28-O-β-D-glucopyranosylester(9)。结论:化合物1为新化合物,化合物2和9为首次从该植物中分离得到。
Objective: To study the chemical composition of Achyranthes bidentata Methods: The structures of the compounds were identified by NMR and other separation methods using D101 macroporous resin, silica gel, ODS and preparative HPLC. Results: Two ferulicin and seven saponins were isolated and identified from Achyranthes bidentata: N-trans-feruloyl-3-methoxytyramine-4’-O-β-D-glucopyranoside -feruloyl-3-methoxytyramine-4-O-β-D-glucopyranoside (2) PJS-1 (3) 28-O-β-D-glucopyranoside (5), oleanolicacid3-O- [β-D-glucuronopyranoside-6-O-ethylester] -28- -D-glucurono-pyranoside-6-O-butylester] -28-O-β-D-glucopyranoside (7), ginsenoside R0 (8) and hederagenin-28-O- β-D-glucopyranosylester (9). Conclusion: Compound 1 is a new compound, and compounds 2 and 9 are isolated from this plant for the first time.