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目的探讨拉贝洛尔协同治疗对妊娠高血压患者妊娠结局的影响。方法选取2013年1月至2014年9月青岛市市立医院东院收治的107例妊娠高血压患者为研究对象,按随机数字表法将其分为分为观察组(54例)和对照组(53例)。对照组患者给予硫酸镁,观察组患者在对照组基础上采用拉贝洛尔进行治疗,比较两组患者治疗前后血压、治疗后尿蛋白消失以及产后出血、软产道损伤发生情况。结果治疗后,观察组患者的收缩压和舒张压均明显低于对照组,差异均有统计学意义(均P<0.05);观察组患者尿蛋白消失率明显高于对照组,软产道损伤及产后出血发生率均明显低于对照组,差异均有统计学意义(均P<0.05)。结论拉贝洛尔联合硫酸镁治疗妊娠高血压,降低产后出血和软产道损伤发生率,对改善妊娠结局具有重要意义。
Objective To investigate the effect of labetalol on pregnancy outcome in patients with pregnancy induced hypertension. Methods A total of 107 cases of pregnancy-induced hypertension in our hospital from January 2013 to September 2014 in Qingdao City Hospital were enrolled and divided into observation group (54 cases) and control group (by random number table) 53 cases). Patients in the control group were given magnesium sulfate. Patients in the observation group were treated with labetalol on the basis of the control group. Blood pressure, disappearance of urine protein after treatment and postpartum hemorrhage and soft birth canal injury were compared between the two groups before and after treatment. Results After treatment, the systolic and diastolic blood pressures in the observation group were significantly lower than those in the control group (all P <0.05). The disappearance rate of urinary protein in the observation group was significantly higher than that in the control group The incidence of postpartum hemorrhage were significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion The combination of labetalol and magnesium sulfate in the treatment of pregnancy-induced hypertension can reduce the incidence of postpartum hemorrhage and soft birth canal injury and is of great significance for improving pregnancy outcome.