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目的：探讨认知行为治疗对神经性皮炎患者心理健康状况及临床疗效的影响。方法将87例神经性皮炎患者按照随机数字表法分为两组，治疗组(44例)予以氟米松软膏联合认知行为疗法治疗，对照组(43例)予以氟米松软膏治疗，观察4周。治疗前后采用症状自评量表评定心理健康状况，并比较两组临床疗效，随访3个月统计患者复发状况。结果治疗4周末治疗组症状自评量表的躯体化、人际敏感、抑郁、焦虑、敌对、偏执因子分均较治疗前显著降低(P<0.05或0.01)，且显著低于对照组(P 0.05)；治疗组痊愈率63.6%、总有效率100%，对照组分别为41.9%、97.7%，治疗组痊愈率显著高于对照组(P<0.05)。随访3个月治疗组复发率显著低于对照组(P <0.05)。结论氟米松软膏联合认知行为疗法治疗神经性皮炎可显著改善患者的心理健康状况，有利于提高临床治愈率，降低复发率。“,”Objective To explore the effects of cognitive behavior therapy (CBT)on mental health status and clinical efficacy of neurodermatitis patients.Methods Eighty-seven neurodermatitis patients were ran-domly divided into treatment group (n =44)was treated with flumetasone ointment plus CBT and control group (n =43)with flumetasone ointment foe 4 weeks.Mental health conditions were assessed with the Symptom Checklist (SCL-90)before and after treatment,efficacies compared between two groups,they followed up for 3 months,and relapse states added up.Results At the end of the 4 th week somatization, interpersonal sensitiveness,depression,anxiety,hostility and paranoia score of the SCL-90 lowered more significantly compared with pretreatment in treatment group (P < 0.05 or 0.01 )and were significantly lower than in those control group (P 0.05);were respectively 63.6% and 100% in treatment and 41.9% and 97.7% in control group,recovery rate was significantly higher in treatment than in control group (P <0.05).The relapse rate was significantly lower in treatment than in control group during 3 month follow-up(P <0.05).Conclusion Flumetasone ointment plus CBT could notably improve mental health levels of neurodermatitis patients and is beneficial to the increase of clinical recovery rate and the decrease of relapse rate.