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目的 探讨病毒感染与慢性阻塞性肺病 (COPD)患者急性发作的关系 ,为临床诊断和治疗提供依据。方法 应用间接酶联免疫吸附试验 (ELISA)对 47例COPD急性发作期患者的血清进行副流感病毒 (PIV)、呼吸道合胞病毒 (RSV)、流感病毒 (IVA/B)、腺病毒 (ADV)的特异性IgM抗体检测。结果 在 35例病例中有1种或 1种以上病毒感染 ,总阳性率为 74 5 %,与正常对照组比较差异有极显著性 (P <0 0 0 1) ,其中以PIV感染率最高 ,阳性率为 5 1%。在 35例病毒感染者中有 30例血象正常 ,且几乎均并发呼吸衰竭或心力衰竭。结论 秋冬季COPD急性发作或加重与呼吸道病毒感染关系密切 ,尤其血象正常而临床症状重者尤应警惕合并有呼吸道病毒的感染。
Objective To investigate the relationship between viral infection and acute exacerbation in patients with chronic obstructive pulmonary disease (COPD), and to provide evidence for clinical diagnosis and treatment. Methods Serum samples of 47 patients with acute exacerbation of COPD were tested for parainfluenza virus (RSV), respiratory syncytial virus (RSV), influenza virus (IVA / B), adenovirus (ADV) by indirect enzyme linked immunosorbent assay (ELISA) Specific IgM antibody test. Results One or more of the 35 cases were infected with the virus. The total positive rate was 74.5%. There was a significant difference between the two groups (P <0.01 01), of which the highest infection rate was PIV, The positive rate was 51%. Thirty of the 35 virus-infected individuals had normal blood counts and almost all had respiratory failure or heart failure. Conclusions The autumn and winter acute episodes or exacerbations of COPD are closely related to respiratory virus infection, especially those with normal blood clots and severe clinical symptoms should be especially vigilant against respiratory virus infection.