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目的:观察希明婷片治疗女性围绝期综合征的临床效果。方法:将诊断为围绝经期综合征的女性患者60例,随机分为试验组和对照组。实验组:口服希明婷片200mg/d。对照组:口服倍美力0.3mg/d。观察治疗前、后潮热出汗、烦躁易怒等围绝经期综合征Kapperman评分变化,B超监测子宫内膜厚度,血、尿常规,肝、肾功能,卵泡刺激素(FSH)、黄体生成素(LH)、雌激素(E2)变化。结果:两组患者治疗1个月后,围绝经期综合征症状均明显改善,比较两组Kapperman评分差别无统计学意义(P>0.05);治疗前后两组生命体征、血尿常规、肝肾功能、激素水平(E2、LH、FSH)及子宫内膜厚度的改变两组间比较差别无统计学意义(P>0.05)。结论:希明婷治疗女性围绝经期综合征有一定效果且副作用小,特别适应于有激素使用禁忌症或对使用雌激素有顾虑的围绝经期患者。
Objective: To observe the clinical effect of xi-ming-ting tablet in the treatment of perinatal syndrome in women. Methods: Sixty female patients diagnosed as perimenopausal syndrome were randomly divided into experimental group and control group. Experimental group: oral Ximing Ting tablets 200mg / d. Control group: Oral beibeili 0.3mg / d. The changes of Kapperman score in perimenopausal syndrome such as hot flashes, irritability and irritability were observed before and after treatment. The thickness of endometrium, blood, urine, liver and kidney function, FSH, (LH), estrogen (E2) changes. Results: After one month treatment, the symptoms of perimenopausal syndrome were significantly improved in both groups, there was no significant difference between the two groups (P> 0.05); before and after treatment, the vital signs, hematuria, liver and kidney function , Hormone levels (E2, LH, FSH) and endometrial thickness changes between the two groups showed no significant difference (P> 0.05). Conclusion: Ximing Ting treatment of women with perimenopausal syndrome have some effects and side effects, especially for those with contraindications to hormone use or concerns about the use of estrogen perimenopausal patients.