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1966 Adelstein 及 Cüppers 首先报告此病,其特征为在婴儿早期突然发生内斜,内斜之前有眼球震颤,双外展神经假性麻痹,注视眼由内转位向外转运动时出现眼球震颤,多数病人,双眼内斜,而有些患者,则为交替注视。作者在连续247例先天性内斜视中,诊断本综合征者有12例,计6例男孩,6例女孩,年龄从6个月至11岁,生后不久,均有突然发生内斜史,在发生内斜视前,父母均不清楚有无眼球震颤或点头情况,除4例患者外,余均在头几个月发生头位转动,头位转动方向,有些患者是恒定
1966 Adelstein and Cüppers first report the disease, which is characterized by a sudden onset of diastole in early infancy, nystagmus before anterior oblique, double abducens nerve paralysis, nystagmus during outward turn of gaze from the internal transposition, Most patients, both eyes were oblique, while in some patients, alternately. In a consecutive 247 cases of congenital esotropia, 12 patients diagnosed with this syndrome, including 6 boys and 6 girls, aged from 6 months to 11 years old, shortly after birth, have a sudden onset of hypotenalism in the Before the occurrence of esotropia, parents are not clear whether nystagmus or nodding, in addition to four patients, the first few have occurred in the first few head rotation, head rotation direction, some patients are constant