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探讨bc1- 2基因重排与肝癌发生的关系。方法 :采用半套式原位聚合酶链反应检测 40例肝细胞癌组织bc1- 2 /JH融合基因。结果 :40例肝细胞癌发生bc1- 2基因重排有 10例 ,阳性率为 2 5 % ,各组织学分级间无明显差异。正常肝组织为阴性。结果说明bc1- 2基因重排并非淋巴瘤的特异改变 ,bc1- 2基因重排在肝细胞癌变中可能起一定作用。
To investigate the relationship between bc1-2 gene rearrangement and the occurrence of hepatocellular carcinoma. Methods : One hundred cases of hepatocellular carcinoma bc1-2/JH fusion gene were detected by half-in-situ polymerase chain reaction. Results: There were 10 cases of bc1- 2 gene rearrangement in 40 cases of hepatocellular carcinoma, the positive rate was 25%. There was no significant difference among histological grades. Normal liver tissue is negative. The results suggest that the bc1-2 gene rearrangement is not a specific change in lymphoma, and that bc1-2 gene rearrangement may play a role in hepatocellular carcinogenesis.