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目的:探讨短期胰岛素泵强化治疗对2型糖尿病患者脂糖代谢及胰岛β细胞功能的影响。方法:选择2013年10月到2015年10月我院收治的2型糖尿病患者86例,随机分为对照组(n=43)和实验组(n=43)。对照组患者给予门冬胰岛素常规治疗,实验组患者给予胰岛素泵强化治疗,两组疗程均为2周。检测并比较两组患者治疗前后血糖、血脂、糖化血红蛋白(Hb A1c)及口服葡萄糖刺激后胰岛β细胞功能指标。结果:治疗后两组患者空腹血糖(FPG)、Hb A1c、总胆固醇(TC)、甘油三酯(TG)及低密度脂蛋白胆固醇(LDL-C)、稳态模型评价-胰岛素抵抗(HOMA-IR)较治疗前均明显下降(P<0.05),高密度脂蛋白胆固醇(HDL-C)、胰岛素曲线下面积(AUC)、稳态模型评价-胰岛β细胞功能(HOMA-β)及0.5h胰岛素浓度/血糖浓度(I30/G30)较治疗前明显升高(P<0.05),且实验组患者以上各指标变化均优于对照组(P<0.05)。结论:短期胰岛素泵强化治疗能明显纠正2型糖尿病患者血糖、血脂水平,改善胰岛β细胞功能,值得在临床上推广应用。
Objective: To investigate the effect of short-term insulin pump intensive treatment on type 2 diabetes patients with glucose and glucose metabolism and pancreatic β-cell function. Methods: Totally 86 patients with type 2 diabetes treated in our hospital from October 2013 to October 2015 were randomly divided into control group (n = 43) and experimental group (n = 43). Patients in the control group were treated with insulin aspart as usual, and patients in the experimental group were given insulin pump intensive therapy. The two courses of treatment were 2 weeks. The levels of blood glucose, blood lipid, Hb A1c and the function of pancreatic β-cells after oral glucose stimulation were detected and compared before and after treatment. Results: After treatment, the fasting blood glucose (FPG), Hb A1c, total cholesterol (TC), triglyceride (TG) and LDL-C and the homeostasis model assessment of insulin resistance (HOMA- IR) significantly decreased (P <0.05), HDL-C, AUC, steady state model-HOMA-β and 0.5h Insulin concentration / blood glucose concentration (I30 / G30) was significantly higher than before treatment (P <0.05), and the above indicators in the experimental group were better than the control group (P <0.05). Conclusion: Short-term intensive insulin pump can significantly correct type 2 diabetes patients with blood glucose and blood lipid levels, improve pancreatic β-cell function, it is worth to promote the clinical application.