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硝酸类药是一种广泛用于缓解心绞痛发作和预防发作的药物.硝酸甘油(NTG)常舌下含用.见效快但持续时间短,而消心痛(ISDN)持续时间长但出现效果较NTG慢.近年研制出一种新剂型ISDN喷雾剂,兼有NTG的速效性和ISDN的持续性.本文就ISDN喷雾剂(E1000)用后的降血压效果和ISDN及其代谢产物血中浓度与舌下用药后的变化进行了比较.12名男性健康受试者,年龄20～22岁,体重55.0～77.5kg,身长166.0～183.6 cm,随机分成两
Nitric acid is a widely used drug for the relief of angina pectoris and seizures. Nitroglycerine (NTG) is often given sublingually with fast but short duration, and long duration of antidiabetic (ISDN) but appears to be more effective than NTG In recent years, a new dosage form of ISDN spray has been developed, which combines the quick-acting of NTG and the persistence of ISDN.This paper reports the hypotensive effect of ISDN spray (E1000) and the effect of ISDN and its metabolites on blood The changes were compared after treatment.A total of 12 male healthy subjects, aged 20-22 years old, weighing 55.0-77.5 kg and standing 166.0-383.6 cm, were randomly divided into two groups