β-淀粉样前体蛋白(APP)是细胞骨架蛋白的重要组成部分,具有多种异构体形式,不同的异构体可能具有不同的生物学作用和中间代谢途径并在疾病如阿尔茨海默病(AD)、肌萎缩侧索硬化症等的发生中发挥不同的作用。为此,我们用RT-多聚酶链反应(RT-PCR)检测了APP在大鼠端脑、脊髓和肾脏中的差异表达模式。 Beta-Amyloid Precursor Protein (APP) is an important component of cytoskeletal proteins and has many isomeric forms. Different isoforms may have different biological roles and intermediate metabolic pathways and are widely used in diseases such as Alzheimer’s disease Disease (AD), amyotrophic lateral sclerosis, etc. play a different role. To this end, we examined the differential expression pattern of APP in rat telencephalon, spinal cord and kidney by RT-PCR.