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目的观察曲美他嗪联合辛伐他汀治疗不稳定型心绞痛(UA)的临床疗效。方法将76例UA患者随机分成两组,治疗组39例,对照组37例。对照组给予硝酸酯类、β受体阻滞剂等常规治疗。治疗组在常规治疗的基础上加用曲美他嗪20 mg,3次/d,辛伐他汀20 mg/d,睡前口服,连服8周。疗程结束后观察心绞痛控制情况及血清总胆固醇(TC)、甘油三酯(TG)变化,并与对照组比较。结果治疗组用药后血清TC和TG明显下降,治疗组的心绞痛控制情况也明显优于对照组(P<0.05)。结论曲美他嗪、辛伐他汀联合治疗UA效果好,不良反应少,值得临床推广。
Objective To observe the clinical efficacy of trimetazidine combined with simvastatin in the treatment of unstable angina pectoris (UA). Methods 76 patients with UA were randomly divided into two groups, the treatment group 39 cases, control group 37 cases. The control group was given nitrates, β-blockers and other conventional treatment. The treatment group was given trimetazidine 20 mg, 3 times / d, simvastatin 20 mg / d on the basis of routine treatment, oral administration before going to bed, even for 8 weeks. Angina control and serum total cholesterol (TC) and triglyceride (TG) were observed after treatment, and compared with the control group. Results After treatment, serum TC and TG decreased significantly in the treatment group, and angina control in the treatment group was also significantly better than that in the control group (P <0.05). Conclusion Trimetazidine and simvastatin combined with UA have a good effect and few adverse reactions, which is worthy of clinical promotion.