目的 区别良、恶性乳腺病变及其预后的判断。方法 标本常规石蜡包埋,HE染色,光镜观察进行病理分型,取典型病例蜡块连续切片,进行AgNOR染色。结果 AgNOR可以作为NOR及其rDNA转录活动的标志。结论 AgNOR颗粒数目、大小、形态和颗粒分型的综合分析对乳腺疾病的鉴别诊断有重要价值。 Objective To distinguish between benign and malignant breast lesions and their prognosis. Methods Specimens were paraffin-embedded, HE stained, and light microscopy were used for pathological typing. The typical cases were consecutively sliced ​​and stained with AgNOR. Results AgNOR can be used as a marker of transcriptional activity of NOR and its rDNA. Conclusion The comprehensive analysis of AgNOR particle number, size, morphology and granule typing has important value in the differential diagnosis of breast disease.