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阿霉素(Adriamycin,Doxorubicin,ADM)是由链丝菌属Streptomyces peucetius var.caesius的发酵液中分离得到的广谱抗肿瘤抗生素,也可自柔红霉素经化学合成制得。它对多种动物实验肿瘤有效,临床使用抗肿瘤谱广,活性强,已在国际上广泛应用,证明是一种较好的抗肿瘤药物,在肿瘤联合用药和综合治疗中占有很重要的地位。实验研究 1.实验抗肿瘤作用阿霉素属蒽环类抗生素,其结构与柔红霉素十分相似,仅在14位碳上的氢原子为羟基取代,二者结构上的微小改变,导致生物活性的显著差异。与柔红霉素相比较,阿霉素
Adriamycin (Doxorubicin, ADM) is a broad-spectrum antitumor antibiotic isolated from the fermentation broth of Streptomyces peucetius var. Caesius. It can also be synthesized chemically from daunorubicin. It is effective on a variety of animal experimental tumors. It is widely used in the world because of its broad anti-tumor spectrum and strong activity in clinical application. It has proved to be a good anti-tumor drug and plays a very important role in the combination therapy and treatment of tumors . Experimental study 1. Experimental anti-tumor effect Adriamycin is an anthracycline antibiotic, its structure is very similar to daunorubicin, hydrogen atoms only in the 14 carbon hydroxyl substitution, the two structural changes slightly, resulting in biological Significant difference in activity. Compared with daunorubicin, doxorubicin